Norrman E, Petzold M, Gissler M, et al. - Findings revealed that the risk of cardiovascular disease or type 2 diabetes did not differ between children born after assisted reproductive technology (ART) and children born after spontaneous conception (SC). For obesity, a small but significant elevated risk was evident for children born post-ART.

• High-quality Nordic registers were combined to select singleton children born following ART (n = 122,429) and SC (n = 7,574,685) between 1984 and 2015 in Norway, Sweden, Finland, and Denmark.

• A diagnosis of cardiovascular disease, obesity or type 2 diabetes was received by 135 (0.11%), 645 (0.65%), and 18 (0.01%) children born post-ART; corresponding values were 10,702 (0.14%), 30,308 (0.74%), and 2,919 (0.04%) for those born post-SC.

• Post-adjustment for measured confounders, there was no elevated risk of cardiovascular disease or type 2 diabetes in children born after ART.

• A reasonably narrow 95% CI was estimated for any cardiovascular disease, excluding effects of a substantial magnitude, while there was a wide 95% CI for type 2 diabetes, not excluding clinically relevant impacts.