Wild RA, Hovey KM, Andrews C, et al. - This study was undertaken to evaluate the utility of cardiovascular disease (CVD) risk scores compared to age or years since menopause for prediction of CVD events in the WHI clinical trials. Researchers designed a randomized clinical trial including a total of 27,347 postmenopausal women age 50 to 79 years between 1993 to 1998. The American Heart Association/American College of Cardiology and Framingham Heart Study risk scores to age or years since menopause all obtained at baseline to predict subsequent CVD events were compared. They further compared absolute event rates, hazard ratios, and C-statistics (Uno Concordance from Cox proportional models). The results demonstrate that CVD risk scores can help distinguish postmenopausal women at higher risk for CVD beyond age or time since menopause. As per the findings, risk scoring that better estimates vascular aging may facilitate CVD risk prevention. Scores can better inform HT risk/benefit discussions when performed prior to initiation of menopausal hormone therapy.