Nestelberger T, Boeddinghaus J, Lopez-Ayala P, et al. - Whether novel cardiovascular biomarkers quantifying different pathophysiological pathways implicated in type 2 myocardial infarction (T2MI) and/or type 1 myocardial infarction (T1MI) may assist clinicians in the rapid differentiation of T2MI vs T1MI, was investigated in this international, multicenter prospective diagnostic study. Lower levels of biomarkers quantifying cardiomyocyte injury but higher levels of biomarkers quantifying endothelial dysfunction, microvascular dysfunction, and/or hemodynamic stress were found in patients with T2MI compared with those with T1MI. Findings revealed that modest discrimination in early, noninvasive diagnosis of T2MI was offered by biomarkers quantifying myocardial injury, endothelial dysfunction, microvascular dysfunction, and/or hemodynamic stress.