Wang G, et al. - In 120 patients undergoing orthotopic heart transplantation, researchers determined if remote ischemic preconditioning (RIPC) combined with remote ischemic postconditioning (RIPostC) attenuates myocardial injury to donor hearts. In a random manner, a total of 60 participants were assigned to an RIPC+RIPostC group and 60 to a control group. They applied four cycles of 5-min of ischemia and 5-min of reperfusion to the right upper limb by a cuff inflated to 200 mmHg (RIPC) and 20 min following aortic declamping (RIPostC) in the RIPC+RIPostC group. A comparison of serum cardiac troponin I (cTnI) levels at 6 h following aortic declamping was considered as primary endpoint. They found that RIPC combined with RIPostC attenuated myocardial injury at 6 h post-aortic declamping, while no improvement of clinical outcomes due to this function was seen.