Scharf EL, Graff-Radford J, Przybelski SA, et al. - In a population cohort, researchers examined the primary midlife and current cardiometabolic risk factors correlated with changes in white matter hyperintensity (WMH) over time. The sample consisted of individuals registered in the Mayo Clinic Study of Aging—a longitudinal population-based study—with ≥ 2 consecutive WMH assessments on fluid-attenuated inversion recovery-magnetic resonance images (n = 554, ≥ 60 years with midlife assessments) and relevant baseline laboratory measures of interest. The strongest predictor of progression in WMH was age. In males, baseline hypertension, midlife hypertension, and baseline fasting glucose were predictive of WMH change. The connections between hypertension and progression of WMH in females were stronger in sensitivity analyses. Baseline serum glucose was linked to an increase in WMH, but was not significant in females in the stratified analysis. Other continuous laboratory measures of vascular risk have not been linked to progressive WMH.