Welsh P, et al. - Among subjects (n=19,501) enrolled in Generation Scotland Scottish Family Health Study, researchers sought to compare and contrast the link of cardiac troponin T (cTnT) and troponin I (cTnI) with cardiovascular disease (CVD) and non-CVD outcomes, and their determinants in a genome-wide association study. The participants were observed over a median duration of 7.8 years. Cox models were used to determine links of each troponin with a composite CVD outcome (1177 events), CVD mortality (n=266), non-CVD mortality (n=374), and heart failure (n=216). Findings revealed distinct upstream genetic causes of low-grade elevations in cTnI and cTnT, with different associations with outcomes. They found a more strong relation of cTnI rises with some CVD outcomes, whereas cTnT was more strongly related to the risk of non-CVD mortality.