Welsh P, et al. - Among 19,501 individuals in Generation Scotland Scottish Family Health Study, researchers intended to compare and contrast the association of cardiac troponin T (cTnT) and cardiac troponin I (cTnI) with cardiovascular disease (CVD) and non-CVD outcomes, as well as their genetic determinants. The participants were followed-up for 7.8 years. Findings revealed strong associations of both cTnI and cTnT with CVD risk in unadjusted models. Five loci (53 individual SNPs) that had GWAS (Genome wide association study) significant links with cTnI, as well as a different set of four loci (4 SNPs) for cTnT, were identified. Findings were suggestive of distinct upstream genetic causes of low grade elevations in cTnI and cTnT. Also, differences were noted with respect to their associations with outcomes. A more strong association of cTnI elevations with some CVD outcomes was evident, whereas cTnT was more strongly related to the risk of non-CVD death.