Graham-Brown MPM, et al. - In a non-randomized controlled trial, in-centre nocturnal haemodialysis (INHD) patients and patients on conventional haemodialysis (HD) were compared in terms of treatment impact on left ventricular (LV) structure, function and myocardial fibrosis. Findings demonstrated that compared with patients on conventional haemodialysis, 6-months of INHD was related to favourable LV remodelling and attenuated myocardial fibrosis.

Methods

• In 13 INHD patients and 12 control patients on conventional HD, a 6-month, non-randomized controlled trial was performed.
• Researchers used cardiac magnetic resonance imaging and native T1 mapping to determine the impacts of treatment on left ventricular (LV) structure, function and myocardial fibrosis.
• They also collected quality-of-life and clinical measures.

Results

• Findings demonstrated that INHD resulted in marked reductions in LV mass (-14.75 vs. +6.54 g; p=0.02), global T1 (-30.62 vs. 0.4 ms; p=0.05) and non-septal native T1 values (-30.93 vs. 8.96 ms; p=0.02) over time.
• Researchers observed significant improvements in serum phosphate (-0.39 vs. +0.02 mmol/L; p=0.03) and reductions in ultrafiltration rates (-2.32 vs. +0.70 mL/h/kg p=0.05) between INHD and controls.