Sugane H, Kataoka Y, Otsuka F, et al. - Because coronary calcification is related to an increased risk of cardiac events, acute coronary syndrome (ACS) attributable to calcified nodule (CN) may show worse clinical result after percutaneous coronary intervention (PCI), and to test this, researchers undertook this retrospective study of 657 ACS patients undergoing PCI with newer-generation drug-eluting stent implantation under intravascular ultrasound guidance. A composite of major adverse cardiac event [MACE = cardiac death + ACS recurrence + target lesion revascularization (TLR)] was assessed as the primary endpoint. More chances of having coronary risk factors, including hypertension, chronic kidney disease, maintenance hemodialysis and a history of PCI, were noted in CN patients. Overall, in ACS patients attributable to CN, an elevated risk of ACS recurrence and TLR was observed which was predominantly driven by the continuous growth and protrusion of the calcified mass.