Cardiac conduction disorders as markers of cardiac events in myotonic dystrophy type 1
Journal of the American Heart Association Sep 04, 2020
Itoh H, Hisamatsu T, Tamura T, et al. - The present study was conducted to assess whether cardiac conduction disorders could predict cardiac events in patients with myotonic dystrophy type 1. This research included a total of 506 patients with myotonic dystrophy type 1 (aged ≥ 15 years; > 50 cytosine‐thymine‐guanine repeats) who were treated between January 2006 and August 2016 in 9 Japanese hospitals for neuromuscular diseases. Researchers tested genetic and clinical backgrounds including health care, activities of daily living, dietary intake, cardiac involvement, and respiratory involvement during follow‐up. Results indicated that a PQ interval ≥240 ms or QRS duration ≥120 ms were independently linked with a greater occurrence of cardiac events vs those with a PQ interval <240 ms or QRS duration <120 ms; these cardiac conduction parameters were not related to sudden death. The results of this study indicated that cardiac conduction disorders are independently correlate with cardiac events; researchers need to further study the occurrence of sudden death and how to predict it.
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