Gupta A, et al. - Using a population-based database, researchers identified variables which are independent predictors of survival in carcinoma ex pleomorphic adenoma (CXPA) of the major salivary glands and evaluated the incidence and management strategies for this rare malignancy. From 1973 to 2015, the Surveillance, Epidemiology, and End Results database was queried for all cases of major salivary gland CXPA. According to results, the parotid gland was the most common site of involvement among the 619 patients identified. Data reported that the 2-year and 5-year disease-specific survival rates were 90.3% and 80.4%, respectively. Facial nerve sacrifice was not a statistically significant predictor of survival on univariate analysis. Findings suggested that CXPA is a rare salivary malignancy with an increased incidence reported over the last decade. Predictors of disease-specific mortality are tumor size > 4 cm, multiple positive lymph nodes, and distant metastatic disease. In order to enhance early detection and survival strategies for this salivary cancer, further study should be carried out.