• Profile
Close

Capecitabine plus bevacizumab vs capecitabine in maintenance treatment for untreated characterised KRAS exon 2 wild-type metastatic colorectal cancer: A retrospective analysis in Chinese postmenopausal women

BMC Gastroenterology Jan 31, 2019

Su J, et al. - In Chinese postmenopausal women with untreated characterized KRAS exon 2 wild-type metastatic colorectal cancer (MCC), researchers assessed the effectiveness and safety of capecitabine (CAP) plus bevacizumab (CAP-B) vs CAP in maintenance treatment following 6-cycle capecitabine, oxaliplatin, and bevacizumab (CAPOXB) induction therapy. For this investigation, prospectively maintained databases from 2012 to 2016 were reviewed to assess cohorts with untreated characterized KRAS exon 2 wild-type MCC and stable disease or better following 6-cycle CAPOXB induction treatment. Study participants included 263 women with untreated characterized KRAS exon 2 wild-type MCC and stable disease or better following 6-cycle CAPOXB induction treatment. In these patients, CAP- B maintenance after 6-cycle CAPOX- B treatment is poorly tolerated and has modest (if any) benefit vs CAP maintenance. Investigators found that the CAP-B-treated cohort had significantly more grade 3 or 4 diarrhea vs the CAP-treated cohort.

Full text available Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay