Hawke LD, et al. - Researchers sought to describe the mental health characteristics, cannabis use, and substance use profiles of youth aged 14 to 24 years seen at the Youth Addiction and Concurrent Disorders Service at the Centre for Addiction and Mental Health, through an age and gender lens. Differences with respect to sex and age were noted in substance use and mental health profiles of cannabis-using youth. Male youth exhibited a higher tendency for using cannabis, while female youth showed a higher tendency for using a greater variety of substances and displaying more co-occurring mental health problems. Adolescent problematic substance use tended to co-occur with externalizing problems whereas problematic young adult substance use tended to co-occur with internalizing problems. Findings thereby suggested the significance of developmentally informed, client-oriented care.