Patel RS, et al. - In this retrospective analysis of the Nationwide Inpatient Sample data (2010–2014), researchers assessed the risk of various substances in young acute myocardial infarction (AMI) inpatients and examined patient demographics and hospital outcomes for significant substance use risk factors. They compared patients, aged 15 to 22 years, with a primary diagnosis for AMI (N = 1,694) with non-AMI (N = 9,465,255) inpatients for odds ratio (OR) of substance use by logistic regression model, adjusted for demographics, medical risk factors, and comorbid substance use. In AMI inpatients, tobacco and cannabis use were most prevalent. Users of cocaine, amphetamine, and cannabis had an increased risk of AMI hospitalization. Angioplasty has been used more in cannabis users compared with others. The in-hospital mortalities were 2.7% and 2%, respectively, in overall AMI cohort and cannabis users, and none in consumers of cocaine or amphetamine. The data presented in this work showed a higher prevalence and significant odds of AMI inpatients with cannabis use, along with the potential cost burdens due to severe morbidity and higher use of treatment modalities. Doctors need to become familiar with the increased use of cannabis and other substances in adolescent and younger populations and the typical presentations of myocardial infarction induced by cannabis.