Church RJ, et al. - Given that current blood biomarkers are suboptimal in the detection and prediction of drug-induced liver injury (DILI), researchers attempted to characterize the natural variability and performance characteristics of 14 promising DILI biomarker candidates. For this investigation, they tested serum or plasma from multiple cohorts of healthy volunteers and DILI patients for microRNA-122 (miR-122), glutamate dehydrogenase (GLDH), total cytokeratin 18 (K18), caspase cleaved K18, glutathione S-transferase α, alpha-fetoprotein, arginase-1, osteopontin (OPN), sorbitol dehydrogenase, fatty acid binding protein, cadherin-5, macrophage colony-stimulating factor receptor (MCSFR), paraoxonase 1 (normalized to prothrombin protein), and leukocyte cell-derived chemotaxin-2. GLDH seems to be more useful in the identification of DILI patients than miR-122, and K18, OPN and MCSFR are promising candidates for prognosis prediction during acute DILI events.