Ebell MH, Bentivegna M, Hulmeet C., et al. - Since there is a lack of clarity about if lung cancer screening using low-dose computed tomography (LDCT) lowers lung cancer–specific and all-cause death, researchers examined its links with outcomes via this meta-analysis. Relevant randomized controlled trials comparing LDCT screening with usual care or chest radiography were identified. Experts analyzed eight trials (including 90,475 patients) that had a low risk of bias. LDCT screening afforded a significant decrease in lung cancer–specific death; the absolute risk reduction was estimated to be 0.4% (number needed to screen = 250). The recommendations to screen people at raised risk for lung cancer with LDCT were supported by the findings of this meta-analysis demonstrating a significant decrease in lung cancer–specific mortality, though with a likely tradeoff of overdiagnosis.