Porter RM, et al. - Researchers performed a 3-arm randomized trial including girls aged 9–17 years, to create a cervical cancer-salient message encouraging Human Papillomavirus (HPV) vaccination, emphasizing disease salience and disease threat, while promoting self-efficacy, with a presumption that this message would have greater effects on vaccine confidence and intent to vaccinate compared to Centers for Disease Control and Prevention (CDC) and non-vaccine control messages. Intent to vaccinate was not influenced by either of these messages. For changing intention, the cervical cancer framed message could be more effective in parents with ‘Low’ vaccine confidence at baseline, compared with the CDC message or non-vaccine control, as suggested in exploratory analyses.