Oishi K, Ito T, Sakonishi D, et al. - Since lymph node metastasis (LNM) occurs in less than 15% of patients with early invasive colorectal adenocarcinoma (T1-CRAC) who undergo surgery following therapeutic endoscopy due to the risk of LNM, researchers constructed an algorithm utilizing histological risk factors to determine the potential use of cancer gland rupture (CGR) in LNM risk assessment in patients (n = 217) with endoscopically resected T1-CRAC with deep invasion. According to results, CGR was characterized by C-shaped cancer glands with a more or less inflammatory or stromal reaction, often followed by mucus-lake or abscess formation. The authors concluded that CGR is an easily applied and objective histological finding to predict LNM that may be useful in assessing endoscopically resected risk for LNM.