Oishi K, Ito T, Sakonishi D, et al. - This study was carried out to assess whether cancer gland rupture as a potential risk factor for lymph node metastasis in early colorectal adenocarcinoma with deep submucosal invasion. Researchers investigated cancer gland rupture (CGR), i.e. cancer glands with a discontinuous epithelial lining, at the invasive front, as a potential risk factor for lymph node metastasis (LNM) by histological examination of differentiated T1-CRAC from 217 individuals who underwent surgery with or without therapeutic endoscopy. The outcomes of this study indicated that cancer gland rupture is an easily used and objective histological finding for prognosticating LNM that could be beneficial for assessing the risk for LNM of endoscopically resected patients with early invasive colorectal adenocarcinoma with deep invasion.