Schmidt M, et al. - Researchers investigated the significance of preoperative serum cancer antigen 125 (CA-125) as a prognostic factor in patients with uterine papillary serous carcinoma (UPSC). Sixty-one women were included on analyzing all women with UPSC operated in their institution between January 2002 and June 2016. In these patients, preoperative CA-125 level showed correlation with known prognostic parameters of endometrial carcinoma and was associated with extrauterine involvement. This underscores the necessity for further evaluation of the role of CA-125 in predicting recurrence and survival in UPSC.