Essa L, et al. – This article was composed with the aim to evaluate dry eye treatment with four preservative–free dry eye artificial tear treatments to facilitate evidence–based prescribing. If prescribed to a general dry eye population, the artificial tears performed similarly, improving symptoms and conjunctival signs. However, osmolarity balanced artificial tears were the preferred treatment in individuals with low baseline tear volume and lipisomal spray for individuals with a baseline lipid layer deficiency.