Ho LM, et al. - When using unenhanced CT, contrast-enhanced CT (CECT), and chemical-shift MRI, researchers ascertained if second-order texture analysis is useful for distinguishing lipid-poor adenomas from malignant adrenal nodules. For this retrospective study, they evaluated 23 adrenal nodules in 20 patients. Between benign and malignant adrenal nodules, lesion size, unenhanced CT attenuation, and the signal intensity index exhibited significant differences. There was no significant difference in the attenuation of CECT. Multivariate logistic regression models displayed that malignancy could be predicted by CECT texture features, chemical-shift MRI texture features, and imaging features. According to findings, texture analysis has a potential role to distinguish between benign and malignant adrenal nodules in CECT and may reduce the need for added imaging studies in working up adrenal nodules that have been discovered by chance.