Dunn JP, et al. - The experts undertook this study to ascertain whether calorie restriction without weight loss modified dopamine (DA) type 2 and 3 receptor (D2/3R) binding potential (BP_ND) and whether such changes were explained by neuroendocrine regulation. Reductions in regional D2/3R availability after very-low-calorie-diet (VLCD) were suggestive of increased endogenous DA competing with the radioligand in obesity. Changes in regional D2/3R availability were correlated with decreases in leptin concentrations that occurred before clinically significant weight loss.