Rizza A, et al. - An analysis was performed to assess standard coagulation assay, thrombin generation by calibrated automated thrombogram (CAT), thromboelastography (TEG) and procoagulant phospholipids (PPL) activity in infants undergoing cardiac surgery with cardiopulmonary bypass (CPB). In children affected by congenital heart disease, thrombin generation was significantly impaired compared to healthy children and adults. In infants aged <6 months, CAT parameters resulted age-dependent, and thrombin generation was lower. Despite transfusions of blood products, a coaugulopathy, revealed by CAT, TEG, but not by PT and aPTT assays, was persistent 12 h after surgery after cardiac surgery with CPB.