Ferreira D, et al. - A retrospective study from 2011 to 2018 was conducted by the researchers on 45 subjects with end-stage kidney disease who underwent total parathyroidectomy with autotransplantation for severe hyperparathyroidism in order to investigate the incidence of hungry bone syndrome (HBS, one of the most serious complications following parathyroidectomy for severe hyperparathyroidism) with pre-operative calcitriol loading for 10 days, to ascertain its risk factors, to discover the rate of intravenous calcium replacement in these patients and to evaluate whether cinacalcet removal had raised rates of parathyroidectomy in the end-stage kidney disease population. Raised parathyroid hormone and longer span of renal replacement therapy were pre-operative variables that were correlated with HBS. Following the removal of calcimimetics from the Pharmaceutical Benefits Scheme, rates of total parathyroidectomy were observed to be higher. Hence, even with extended high-dose calcitriol loading, HBS persisted to be a frequent complication of parathyroidectomy, emphasizing the necessity for further trials examining other targeted therapies, such as bisphosphonates, to restrict HBS. Moreover, subjects with high bone turnover and extended renal replacement therapy were most commonly at risk of HBS.