Calcinosis cutis in the setting of chronic skin graft-versus-host disease
JAMA May 24, 2020
Saardi KM, Rosenstein RK, Anadkat MJ, et al. - In this study, the researchers sought to identify patients with chronic graft-versus-host disease (cGVHD) with calcinosis in order to explore predisposing factors and clinical characteristics. A known sequela of systemic sclerosis (SS) is calcinosis cutis. SS and sclerotic-type chronic skin graft-versus-host disease (ScGVHD) share many clinical and histological characteristics, however, high-titer antibodies specifically related to SS are not typically found in ScGVHD, and the fibrotic features in ScGVHD more closely resemble morphea and eosinophilic fasciitis.
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