Zhou C, Liu XB, Gan XJ, et al. - A meta-analysis was conducted to evaluate the calcification sign for prediction of benignity in pulmonary nodules. Between January 2000 and October 2020, Cochrane Library, Embase, and PubMed were considered as a reference to obtain the required data. Researchers used Stata v12.0 as a standard tool for statistical assessment. Via this meta-analysis, eleven retrospective studies were evaluated, which enrolled 6,136 pulmonary nodules (1,827 benign and 4,309 malignant). The findings revealed that calcification signs have been distinguished as moderate regulators corresponding to overall diagnostic performance (via marking a distinct differentiation between malignant and benign) for pulmonary nodules. Nevertheless, for benign PNs, the manifestation of the calcification sign had a good directive property.