Cheng H, et al. - As propolis’ efficacy in attenuating neuropathic pain is becoming more evident, researchers investigated caffeic acid phenethyl ester (CAPE), the main ingredient of propolis, for its effects and the possible mechanism in improving neuropathic pain via its inhibition on p38/NF-κB signal pathway in microglia. For this purpose, they used chronic constriction injury (CCI) mice model and the microglial cell line BV-2. Findings suggest that by powerfully inhibiting the P38/NF-κB signal pathway, CAPE is an effective and safe drug for alleviating neuropathic pain.