Balestracci A, et al. - Researchers looked for a link between C3 levels on admission and worse acute outcomes in patients with hemolytic uremic syndrome related to Shiga toxin–producing Escherichia coli (STEC-HUS). They compared dialyzed and non-dialyzed patients as well as those with or without extrarenal complications, in terms of demographic, clinical, and laboratory variables. This study included 49 children, with 33 having normal and 16 having reduced C3 levels. An independent association of leukocyte count and C3 level with a complicated disease was revealed in the multivariate analysis. Findings also revealed a correlation of C3 levels with dialysis length; nevertheless, dialysis requirement and extrarenal complications could not be discriminated by these. In this study, a link was observed between reduced C3 levels at admission and a more complicated STEC-HUS episode.