Knaak C, Vorderwülbecke G, Spies C, et al. - Given the risk of developing post-operative delirium (POD) and that post-operative neurocognitive disorder (NCD) might exist in the presence of inflammation prior to surgery, researchers undertook this observational study to investigate the links between preoperative C-reactive protein (CRP) and the incidence of POD and postoperative NCD. This investigation was performed using a cohort of 314 patients registered in the SuDoCo trial, with a preoperative CRP measurement done on the day before surgery. Findings revealed an independent association of preoperative CRP levels with POD but not with postoperative NCD following 3 months. Moreover, higher risk for POD was demonstrated by higher preoperative CRP levels. Overall, the role of inflammation in POD development was reinforced. Risk stratification of POD might be done by evaluating CRP prior to operation.