Evans CR, Long DL, Howard G, et al. - Given that both higher stroke incidence and C-reactive protein (CRP) concentrations have been reported in blacks vs white individuals, researchers investigated the link between CRP with ischemic stroke risk in black and white individuals in an observational cohort study. Participants included 30,239 black and white Americans aged 45 years and older. For ischemic stroke, HRs and 95% CIs were calculated by CRP category (< 1, 1-3, 3-10, and ≥ 10 mg/L) adjusted for age, sex, and stroke risk factors. The follow-up of 6.9 years revealed 292 incident ischemic strokes among black individuals and 439 in whites individuals. White Americans demonstrated elevated risks for CRP in the range from 3 to 10 mg/L; these individuals showed an even higher risk for CRP > 10 mg/L, whereas black Americans demonstrated a link only for CRP > 10 mg/L. Findings revealed that the utility of CRP for stroke risk evaluation may not be equal in black and white individuals.