Kudou K, et al. - In patients who underwent surgery for adenocarcinoma of the esophagogastric junction (AEG) and upper gastric cancer (UGC), researchers examined the prognostic value of the C-reactive protein (CRP)/albumin (Alb) ratio. In patients who underwent surgery for AEG and UGC, the CRP/Alb ratio was strongly related to poor prognosis.

Methods

• For this investigation, researchers reviewed data for 144 subjects who had surgery for AEG and UGC.
• After that, the CRP/Alb ratio, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), Glasgow Prognostic Score (GPS), and controlling nutritional status (CONUT) score were calculated.
• Finally, the association between these biomarkers and postoperative prognosis was analyzed.

Results

• The study results showed that the optimal cut-off value of the CRP/Alb ratio was determined to be 0.1.
• Patients were divided into two groups (CRP/Alb < 0.1, n = 124; CRP/Alb ≥ 0.1, n = 20) according to the cut-off value of CRP/Alb ratio.
• It was observed that the 5-year recurrence-free survival (RFS) and overall survival (OS) rates were significantly lower in the patients with the CRP/Alb ratio ≥ 0.1 vs those with the CRP/Alb ratio < 0.1 (RFS: 44.9% vs. 77.9%, P=0.0011; OS: 43.4% vs. 82.0%, P < 0.0001).
• In the multivariate analyses, the N-stage, and CRP/Alb ratio ≥ 0.1 were determined as independent predictive factors for OS in subjects with AEG and UGC (P=0.0061 and P=0.0439, respectively).