Niederhaus SV, et al. - In this multicenter retrospective study performed by transplantation Committee researchers estimated if undetectable serum C-peptide levels correspond to center-reported pancreas graft failures. They studied C-peptide data from 7 participating centers (n = 415 graft failures for transplants) as pretransplant, at graft failure, and at return to insulin. Graft failure was reported at varying levels of C-peptide for recipients with pretransplant C-peptide <0.75 ng/mL who had a posttransplant C-peptide value available (n = 61). Pancreas graft failure at varying levels of C-peptide was declared by transplant centers and did not consistently report C-peptide data. They did not observe the need for reporting posttransplant C-peptide levels in OPTN. They avoided the use of C-peptide levels as an individual criterion to define pancreas graft failure.