Lin SH, et al. - Researchers investigated c-MYC expression in 133 OSCC patients using immunohistochemical staining, and determined its correlation with clinicopathological parameters. The majority of OSCC patients expressed c-MYC. The patients displayed a correlation of c-MYC expression with histological grade of oral squamous cell carcinoma. As per multivariate Cox regression analysis, TN stage, American Joint Committee on Cancer stage, and tumor differentiation, except c-MYC expression, were independent factors for overall survival in OSCC patients. Kaplan–Meier survival analysis revealed better survival for oral cancer patients (T III/IV stage) with high c-MYC expression vs those with low and medium c-MYC expression. These findings support the potential utility of c-MYC as a biomarker that can be targeted for managing OSCC patients with T stage (III/IV).