Korolainen MA, Tuominen S, Kurki S, et al. - Researchers investigated the overall morbidity and phenotypic diseasome for migraine among individuals of working age using real-world data gathered as a part of routine clinical practice. They conducted this retrospective analysis including electronic medical records (EMR) of patients with migraine (n = 17,623) and age- and gender-matched controls (n = 17,623). The prevalence of ICD-10 codes was assessed in EMRs; inclusion was performed of those with at least two significant phi correlations, and a prevalence > 2.5% in migraine patients to phenotypic disease networks (PDN) for further analysis. Among patients with migraine vs controls, a 1.7-fold increased mean number of diagnoses was evident per patient. Altogether EMRs of migraine patients had 1,337 different ICD-10 codes. Multiple different approaches in the study here suggest an association of migraine with an increased multimorbidity. Migraine patients exhibit a systematic increase in the morbidity across the whole spectrum of ICD-10 coded diagnoses, and when interpreting PDNs. However, the morbidity could not be explained by any specific diagnosis. Results thereby reflect clinical praxis, as well as, the pathophysiological phenotypes linked to migraine, and highlight the value of better understanding concerning migraine-related morbidity.