Cohen D, et al. - For the years 2000–2013, researchers compared data for all reported culture-proven S. sonnei shigellosis cases in children aged 0–59 months in the city of Elad (ultraorthodox community) with data for the rest of the sub-district in order to determine the incidence and risk factors of S. sonnei shigellosis in children. Cyclic epidemics of Shigella sonnei shigellosis occurred every 2 years during 2000–2013. Elad showed 2.6-fold higher incidence compared to the sub-district. S. sonnei shigellosis was noted to be positively associated with concurrent diarrheal disease in family members, having the same person in the daycare center responsible for food handling and changing diapers, and more rooms and sinks in the center, while it had an inverse association with children’s hand-washing before meals. Findings thus suggest the requirement for enhanced hygiene interventions for epidemic control.