Pourali SP, Gutierrez Y, Kohn AH, et al. - In this study, the current evidence on the association between bullous skin disease and depression has been synthesized and interpreted.

• From the PubMed, Embase, PsycInfo, and Cochrane databases, researchers identified a total of 17 articles involving 83,910 patients (55.2% female; specifically, 6,951 patients with bullous pemphigoid, 1,669 patients with pemphigus, and 79 patients with epidermolysis bullosa were analyzed).

• Findings revealed that the prevalence of depressive symptoms ranged from 40% to 80% among patients with bullous dermatoses.

• The prevalence of depression diagnosis ranged from 11.4% to 28% among patients with bullous dermatoses.

• Overall patients with bullous skin disease exhibit high rates of depression and depressive symptoms.

• The burden of mental health on patients may reduce in correlation with undertaking adequate treatment of bullous dermatoses.