Budesonide facilitates weaning from mechanical ventilation in difficult-to-wean very severe COPD patients: Association with inflammatory mediators and cells
Journal of Critical Care Nov 08, 2017
Hashemian SM, et al. - This study was designed to investigate if inhaled budesonide decreases time-to-weaning in COPD stage 4 difficult-to-wean patients and attenuates the release of pro-inflammatory cytokines in intensive care unit (ICU) patients. It was observed in COPD patients on MV that nebulized budesonide was related not only to reduced BAL CXCL8 and IL-6 levels and neutrophil numbers but also to an improvement in ventilatory mechanics and facilitated weaning.
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