Campo P, Eguiluz-Gracia I, Plaza-Serón MC, et al. - Researchers focused on the possibility of the existence of a bronchial counterpart of local allergic rhinitis (LAR). Participants were LAR (n = 28), allergic rhinitis (AR) (n = 18), and nonallergic rhinitis (NAR) patients (n = 19) self-reporting bronchial symptoms indicative of asthma and 8 healthy controls (HC). The participants were asked to undergo a methacholine test (MT) prior to (Visit 1) and 24 hours following (Visit 3) a bronchial provocation test with Dermatophagoides pteronyssinus (BPT-DP) (Visit 2). In these respective groups, a positive MT was identified in 50%, 83.3%, 57.89%, and in 0% of patients at V (visit) 1. In 8 LAR and 15 AR patients, BPT-DP was found positive, with no positive responses in NAR and HC. At V3 vs V1, a significant reduction of PC₂₀ was noted in all BPT-DP+ patients. At V3 vs V1, a significant rise of eosinophils, monocytes, and eosinophil cationic protein in induced sputum was evident in BPT-DP+ patients. Overall, a novel asthma phenotype (local allergic asthma), defined by the absence of systemic atopy and positivity to bronchial provocation test with allergen, was shown to be existing.