Visscher DW et al. -Women with benign breast biopsies are at increased risk for breast cancer, with risk stratified on histologic categories of epithelial proliferation. In the current study, women who had serial benign biopsies performed over time were assessed and how changes in the histologic classification affect breast cancer risk were determined.It was shown that breast cancer risk increases in women with progressive epithelial proliferation over time and decreases in women with biopsies that show less proliferation.