Negrão EMS, et al. - Researchers undertook this retrospective analysis to determine the factors that may impact magnetic resonance imaging (MRI) performance in the identification of pathologic complete response (pCR) following neoadjuvant chemotherapy (NAC). They analyzed 219 patients with invasive breast carcinoma. These patients had undergone breast MRI prior to and following NAC. They compared MRI-generated results with gold standard pathological examinations. They defined pCR as the resolution of invasive breast disease. Among the breast cancer patients studied, the prediction of pCR after NAC was enabled by MRI with good accuracy. However, findings revealed a negative influence of non-mass enhancement at pretreatment MRI on the diagnostic performance of MRI in evaluating therapy response post-NAC.