Danieli L, et al. - Fifty-four contrast-enhancing tumors (38 gliomas and 16 metastases) were evaluated using MPRAGE (most commonly used 3D MR imaging technique), volumetric interpolated brain examination (VIBE), and sampling perfection with application-optimized contrasts by using different flip angle evolutions (SPACE) techniques randomly collected following gadolinium-based contrast agent administration on a 3T scanner by the researchers in order to compare brain tumor enhancement visualization and the “target” object morphometry obtained from the formerly mentioned techniques. In both gliomas and metastases, both SPACE and VIBE obtained a greater contrast rate, contrast-to-noise ratio, and visual conspicuity ratings in comparison with MPRAGE. The between-sequence 3D target object margin error ranged between 3% and 19.9% of lesion tumor volume. Greater tumor volumes, 1D and 2D measurements were obtained with the help of SPACE. Hence, in contrast with MPRAGE, superior conspicuity for brain tumor enhancement could be accomplished using SPACE and VIBE techniques. Moreover, when evaluating target object size and morphology, discrepancies were also recognized with SPACE rendering more exact estimates.