Rebelos E, et al. - Given that insulin enhances brain glucose uptake (BGU) in obese but not lean subjects, researchers explored this finding by combining BGU with measures of endogenous glucose production (EGP) and examined the relationships between insulin-stimulated BGU and peripheral markers like metabolites and inflammatory markers via recruiting 20 morbidly obese and 12 lean controls from the larger randomized controlled SLEEVEPASS study. A positive correlation was seen between BGU and EGP during insulin stimulation in obese patients. It was noted that insulin-stimulated BGU correlated positively with systemic inflammatory markers and plasma levels of leucine and phenylalanine. This investigation suggests the presence of a brain-liver axis in morbidly obese individuals, which endures postoperatively. Findings revealed that this axis could contribute to further deterioration of glucose homeostasis.