Geevasinga N, et al. - In order to provide novel insights into amyotrophic lateral sclerosis (ALS) pathogenesis, the physicians used a multimodality approach encompassing connectome network combined with brain volume analysis and assessment of cortical excitability. In ALS patients, multimodal assessment of cortical function had identified deficits in functional connectivity associated with cortical hyperexcitability that correlated with patient disability. Novel integration of functional brain assessment further added to understanding disease pathogenesis in ALS.