Santoro JD, et al. - Researchers attempted to compare regional cerebral volumes and diffusion in tension-type and migraine-type headaches against published controls. From May 2014 to July 2016, patients evaluated for tension-type or migraine-type headache without aura in a single center were retrospectively reviewed. They enrolled 32 patients with tension-type headache and 23 with migraine-type headache at an average of 4 months after diagnosis. They identified early cerebral diffusion changes in patients with tension-type and migraine-type headaches compared with controls. Data reported that the hypothesized mechanisms of nociception in migraine-type and tension-type headaches could explain the findings as a precursor to structural changes seen in adult patients with chronic headache.