Brett FM, et al. – This trial investigated if better case selection could reduce the necessity for application of Creutzfeldt–Jakob disease (CJD) risk precautions. The clinical suspicion of CJD was not borne out by the final neuropathological diagnosis. Failure by clinicians to adhere to the recommended CJD investigation algorithm exerted an adverse effect on the neuropathology workload. It resulted in unnecessary concern among operating theatre, laboratory and nursing personnel.