Findings demonstrated that clinical and dermoscopic features were similar between V600E and V600K mutated melanomas. Relative to BRAF V600E melanomas, the trend of BRAf V600k would be less responsive to the therapies employed and with a worse prognosis.

• A total of 132 cases of B-RAF V600E mutated melanomas were randomized with a propensity-score method to match 10 retrieved cases of B-RAF V600K.

• Both groups were characterized by nodular aspect and a high disease stage.

• Dermoscopic characteristics did not differ significantly between groups.

• Deaths from disease-specific causes occurred in 4 patients with BRAF v600k.

• In BRAF V600K melanoma cases, a higher frequency of metastasis, a faster disease progression and more rapid mortality were evident.