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Borderline pulmonary hypertension is associated with exercise intolerance and increased risk for acute exacerbation in patients with interstitial lung disease

BMC Pulmonary Medicine Sep 09, 2019

Nemoto K, Oh-ishi S, Akiyama T, et al. - Among patients with interstitial lung disease (ILD) (n = 80), researchers investigated the influence of borderline pulmonary hypertension (PH) on the exercise capacity, risk of acute exacerbation (AE), and mortality. Participants had undergone right heart catheterization between November 2013 and October 2016. Three groups were defined based on mean pulmonary artery pressure (mPAP) values: mPAP ≤ 20 mmHg (No-PH group; n = 56), 20 < mPAP < 25 mmHg (Bo-PH group; n = 18), and mPAP ≥ 25 mmHg (PH group; n = 6). A possible link of borderline PH with poorer exercise tolerance and an increased risk of AEs was suggested among the participants. In Kaplan-Meier analysis, the 1-year survival rate did not differ significantly between the three groups. Based on these findings, the experts recommended the physicians to pay close attention to the presence of even mild rise of the mPAP at the initial assessment in patients with ILD.
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