Sarkissian A, et al. - In patients with established systemic lupus erythematosus (SLE), authors sought to examine bone turnover markers in relation to vitamin D, disease activity, and clinical risk factors. They assessed the clinical registry and biorepository data of 42 SLE patients. Findings suggested the probability of SLE disease activity to have direct impacts on bone formation, but this disease activity has no effects on bone resorption in this cohort of established SLE patients, probably related to the inflammation-suppressing effects of glucocorticoids, thereby inhibiting cytokine-induced osteoclast activity. They noted a fine balance between disease control and the use of glucocorticoids with regard to bone health.