Madsen JOB, et al. - In this investigation, researchers assessed type-1-diabetes (T1D) bone turnover markers in children and adolescents, and through meta-analysis, whether changes in OCN, P1NP and CTX are seen and if potential changes are related to metabolic control (HbA1c). There were 26 studies included with data from over 1,000 T1D patients. In children and adolescents with T1D, OCN is significantly lower vs healthy controls. Due to the very limited data available, it is unclear whether CTX and P1NP are also affected. In order to further elucidate the status of bone turnover in children and adolescents with T1D, large studies with OCN, P1NP and CTX (as Z-scores adjusting for age-variability) are required.